Figure 7.

Separation process of S2 and S1 with three Nrp1s, i.e., one binding to each unit of the Spike protein trimer. (a) Snapshots and the displacement of the S2 domain relative to initial position are shown. (b) Pulling force versus displacement of the S2 domain with three Nrp1 bound. Data are shown as averaged over two simulations for model 1 (red), that is the separation of two times three S1:S2 contacts, whereas the ACE2 data are taken from Fig. 4b. To see this figure in color, go online.