Table 3.

Study design, methods, and results of studies that found conflicting effects following treatment.

Study	No. of eyes	Design of study	Imaging modality	Agent used and treatment duration	Outcome measure	Study results	Ref.
Busch et al.	23 eyes of 23 patients with DME	Retrospective case series	OCTA (Optovue) 3 × 3 scan using machine software for VD	Aflibercept (1-8 monthly injections)	Change in built-in machine VD and FAZ	SCP FAZ increased by 0.07 mm2 and DCP FAZ decreased by 0.04 mm2 (p > 0.05)	[45]
Dastiridou et al.	20 eyes of 20 patients with DME	Prospective case series	Swept source OCTA (Topcon) 6 × 6 and 7 × 7 scans	Aflibercept (3 injections)	Change in FAZ area and VD	FAZ of DCP and VD of central area decreased (p ≤ 0.05)	[46]

DCP: deep capillary plexus; DME: diabetic macular edema; FAZ: foveal avascular zone; OCTA: optical coherence tomography angiography; SCP: superficial capillary plexus; VD: vascular density.