TABLE 1.
The univariate and multivariate analyses of factors associated with overall survival in LUSC cases
| Variable | N (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |||
| Age (years) | <60 | 88 (46.3) | 0.743 (0.510–1.083) | 0.122 | 0.684 (0.466–1.005) | 0.053 |
| ≥60 | 102 (53.7) | |||||
| Gender | Male | 183 (96.3) | 1.435 (0.455–4.521) | 0.537 | 1.101 (0.345–3.517) | 0.871 |
| Female | 7 (3.7) | |||||
| Smoking history | Smokers | 176 (92.6) | 0.852 (0.396–1.830) | 0.681 | ||
| Nonsmokers | 14 (7.4) | |||||
| Differentiation | Poor | 95 (50.0) | 1.415 (0.973–2.059) | 0.069 | 1.590 (1.073–2.357) | 0.021 |
| Moderate and high | 95 (50.0) | |||||
| T | 1–2 | 124 (65.3) | 0.364 (0.250–0.531) | <0.001 | 0.437 (0.297–0.643) | <0.001 |
| 3–4 | 66 (34.7) | |||||
| N | 0–1 | 131 (68.9) | 0.421 (0.282–0.602) | <0.001 | 0.399 (0.268–0.595) | <0.001 |
| 2 | 59 (33.1) | |||||
| TNM stage | 1–2 | 104 (54.7) | 0.344 (0.235–0.504) | <0.001 | ||
| 3 | 86 (45.3) | |||||
| PD‐L1 | Positive | 51 (26.8) | 1.504 (1.007–2.248) | 0.046 | ||
| Negative | 139 (73.2) | |||||
| CD47 | Positive | 124 (65.3) | 1.866 (1.232–2.826) | 0.003 | ||
| Negative | 66 (34.7) | |||||
| PD‐L1/CD47 | Co‐expression | 45 (23.7) | 1.613 (1.069–2.435) | 0.023 | 1.922 (1.245–2.969) | 0.003 |
| Others | 145 (76.3) | |||||
Abbreviations: CD47, cluster of differentiation 47; CI, confidence interval; HR hazard ratio; LUSC, lung squamous cell carcinoma; PD‐L1, programmed cell death‐ligand 1.