TABLE 2.
The univariate and multivariate analyses of factors associated with overall survival in LUAD cases
| Variable | N (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |||
| Age (years) | <60 | 122 (50.8) | 0.548 (0.399–0.753) | <0.001 | 0.535 (0.387–0.739) | <0.001 |
| ≥60 | 118 (49.2) | |||||
| Gender | Male | 143 (59.6) | 1.223 (0.887–1.685) | 0.220 | 1.279 (0.915–1.789) | 0.150 |
| Female | 97 (40.4) | |||||
| Smoking history | Smokers | 108 (45.0) | 0.784 (0.574–1.072) | 0.127 | ||
| Nonsmokers | 132 (55.0) | |||||
| Differentiation | Poor | 133 (55.4) | 1.248 (1.063–1.465) | 0.007 | 1.094 (0.921–1.299) | 0.306 |
| Moderate and high | 107 (44.6) | |||||
| T | 1–2 | 176 (73.3) | 0.737 (0.623–0.872) | <0.001 | 0.625 (0.440–0.887) | 0.009 |
| 3–4 | 64 (36.7) | |||||
| N | 0–1 | 148 (61.7) | 0.483 (0.353–0.661) | <0.001 | 0.492 (0.354–0.684) | <0.001 |
| 2 | 92 (38.3) | |||||
| TNM stage | 1–2 | 129 (53.8) | 0.494 (0.361–0.677) | <0.001 | ||
| 3–4 | 111 (46.2) | |||||
| PD‐L1 | Positive | 45 (18.8) | 1.517 (1.041–2.210) | 0.030 | ||
| Negative | 195 (81.3) | |||||
| CD47 | Positive | 172 (71.7) | 1.470 (1.026–2.106) | 0.036 | ||
| Negative | 68 (28.3) | |||||
| PD‐L1/CD47 | Co‐expression | 35 (14.6) | 1.815 (1.204–2.736) | 0.004 | 1.549 (1.015–2.364) | 0.043 |
| Others | 205 (85.4) | |||||
Abbreviations: CD47, cluster of differentiation 47; CI, confidence interval; HR hazard ratio; LUAD, lung adenocarcinoma; PD‐L1, programmed cell death‐ligand 1.