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CDK4/6 inhibitor palbociclib combined with osimertinib restrained H1975OR and downregulated Snail. (a, b) Osimertinib (2.5 and 1.25 μM) combined CDK4/6 inhibitor palbociclib 1.25 μM increased inhibition of H1975OR. (c) Osimertinib (2.5 μM) and combined CDK4/6 inhibitor palbociclib (1.25 μM) downregulated Snail. (d) The mRNA of Snail and DUB3 in H1975 and H1975OR
