Table 1.
Blood routine parameter and biomarker values of non-ICU group and Control group on admission.
| Non-ICU | Control | p-value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex Male (%) Female (%) |
1219 (49.6) 1239 (50.4) |
1293 (48.8) 1355 (51.2) |
0.585 | |||||||||
| Mean | Median | Min | Max | St D | Mean | Median | Min | Max | St D | |||
| Age | 53.6 | 55.0 | 18.0 | 102.0 | 18.6 | 49.0 | 48.0 | 18.0 | 102.0 | 19.5 | 0.000*** | |
| Blood routine parameters | CRP (mg/L) | 22.2 | 6.1 | 3.0 | 406.0 | 36.5 | 9.4 | 4.1 | 1.0 | 330.0 | 24.7 | 0.000*** |
| D-Dimer (μg/L) | 545.1 | 391.0 | 1.06 | 9240.0 | 684.44 | 404.0 | 391.0 | 104.0 | 9610.0 | 249.01 | 0.000*** | |
| Ferritin (μg/L) | 183.7 | 49.2 | 2.2 | 1650.0 | 281.8 | 55.0 | 49.2 | 0.2 | 1650.0 | 65.2 | 0.000*** | |
| Fibrinogen (mg/L) | 320.5 | 308.6 | 90.2 | 668.1 | 55.3 | 308.7 | 308.6 | 169.9 | 437.8 | 7.2 | 0.000*** | |
| INR | 1.11 | 1.10 | 0.8 | 17.8 | 0.4 | 1.2 | 1.15 | 0.8 | 7.0 | 0.4 | 0.620 | |
| PT (Sec) | 13.3 | 13.0 | 10.1 | 181.0 | 4.0 | 13.6 | 13.0 | 9.1 | 74.9 | 3.8 | 0.698 | |
| Procalcitonin (μg/L) | 0.2 | 0.1 | 0.1 | 24.0 | 0.6 | 0.1 | 0.1 | 0.1 | 27.0 | 0.8 | 0.000*** | |
| ESR (mm/h) | 17.8 | 11.0 | 2.0 | 124.0 | 18.0 | 13.9 | 11.0 | 2.0 | 120.0 | 10.8 | 0.000*** | |
| Troponin (ng/L) | 18.3 | 10.0 | 10.0 | 420.0 | 13.9 | 33.3 | 10.0 | 10.0 | 2500.0 | 541.9 | 0.889 | |
| aPPT (Sec) | 31.2 | 29.8 | 12.0 | 101.0 | 5.5 | 30.3 | 29.8 | 12.0 | 101.0 | 4.1 | 0.000*** | |
| PLT. ×109/L | 241.6 | 229.0 | 11.0 | 745.0 | 89.1 | 261.6 | 253.0 | 9.0 | 768.0 | 74.2 | 0.000*** | |
| LYM. ×109/L | 1.7 | 1.4 | 0.1 | 90.3 | 3.0 | 2.3 | 2.1 | 0.2 | 60.5 | 1.8 | 0.000*** | |
| NEU. ×109/L | 5.3 | 4.3 | 0.5 | 66.4 | 3.8 | 5.1 | 4.5 | 0.8 | 22.2 | 2.6 | 0.001** | |
| WBC. ×109/L | 7.7 | 6.7 | 0.4 | 127.0 | 5.2 | 8.2 | 7.6 | 1.5 | 68.3 | 3.3 | 0.000*** | |
| Biomarkers in the literature | LCR | 0.3 | 0.2 | 0.01 | 22.5 | 0.7 | 0.4 | 0.2 | 0.01 | 6.3 | 0.3 | 0.000*** |
| PLR | 214.5 | 155.2 | 1.6 | 3054.6 | 185.0 | 138.0 | 118.8 | 3.1 | 2527.3 | 93.2 | 0.000*** | |
| NLR | 5.8 | 2.7 | 0.1 | 255.7 | 10.9 | 2.8 | 2.1 | 0.1 | 50.9 | 2.9 | 0.000*** | |
| d-NLR | 3.3 | 1.9 | 0.1 | 84.0 | 4.2 | 1.9 | 1.5 | 0.1 | 25.5 | 1.5 | 0.000*** | |
| Biomarkers derived in this study | d-CL | 21.2 | 5.5 | 0.04 | 1923.1 | 59.3 | 5.19 | 1.25 | 0.1 | 357.1 | 16.5 | 0.000*** |
| d-CWL | 3.57 | 0.83 | 0.0 | 209.8 | 10.6 | 0.77 | 0.26 | 0.0 | 53.1 | 2.7 | 0.000*** | |
| d-CFL | 6663.4 | 450.0 | 2.18 | 621117.5 | 27224.5 | 341.1 | 95.2 | 0.16 | 56713.3 | 1887.6 | 0.000*** | |
| d-CI | 23.3 | 7.3 | 3.9 | 407.1 | 36.5 | 10.5 | 5.2 | 2.1 | 331.1 | 24.7 | 0.000*** | |
| d-CT | 414.7 | 64.1 | 30.0 | 195670.0 | 4916.1 | 326.3 | 40.7 | 10.0 | 335800.0 | 7118.9 | 0.000*** | |
| d-TI | 20.2 | 10.9 | 8.3 | 4578.0 | 146.9 | 41.1 | 10.9 | 7.5 | 37000.0 | 769.5 | 1.00 | |
| d-PPT | 42.15 | 15.6 | 12.1 | 8977.8 | 320.9 | 62.1 | 15.6 | 10.9 | 52200.0 | 1091.9 | 0.000*** | |
| d-CIT | 460.4 | 70.3 | 25.1 | 213280.3 | 5475.6 | 384.8 | 44.3 | 10.9 | 366022.0 | 8217.7 | 0.000*** | |
aPPT: activated partial prothrombin time; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; INR: international normalized ratio PT: prothrombin time; d-NLR: neutrophil count divided by the result of WBC count minus neutrophil count; LCR: lymphocyte to C-reactive protein ratio; NLR: neutrophil to lymphocyte ratio; PLR: platelet to lymphocyte ratio; INR: international normalized ratio; PLT: platelet count; LYM: lymphocyte count; WBC: white blood cell count; NEU: neutrophil count;; d-CL: CRP to lymphocyte ratio; d-CWL: CRP divided by WBC times LYM; d-CFL: CRP times Ferritin result divided by LYM; d-CI: CRP times INR; d-CT: CRP times Troponin; d-TI: Troponin times INR; d-PPT: PT times Procalcitonin times Troponin; d-CIT: CRP times INR times Troponin (see method section). Bold p values were found to be significant. *p < 0.05, **p < 0.01, ***p < 0.001 was considered significant. St D: Standart Devision.