Table 2.
Blood routine parameter and biomarker values of ICU group and Control group on admission.
| ICU | Control | p-value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex Male (%) Female (%) |
114 (60.0) 76 (40.0) |
1293 (48.8) 1355 (51.2) |
0.003** | |||||||||
| Mean | Median | Min | Max | St. D | Mean | Median | Min | Max | St D | |||
| Age | 72.9 | 75.0 | 20.0 | 100.0 | 11.9 | 49.0 | 48.0 | 18.0 | 102.0 | 19.5 | 0.000*** | |
| Blood routine parameters | CRP (mg/L) | 78.0 | 54.5 | 3.0 | 325.0 | 77.2 | 9.4 | 4.1 | 1.0 | 330.0 | 24.7 | 0.000*** |
| D-Dimer (μg/L) | 1049.8 | 391.0 | 353.0 | 9610.0 | 1755.1 | 404.0 | 391.0 | 104.0 | 9610.0 | 249.0 | 0.000*** | |
| Ferritin (μg/L) | 345.9 | 49.2 | 49.2 | 1650. | 493.2 | 55.0 | 49.2 | 0.2 | 1650.0 | 65.2 | 0.000*** | |
| Fibrinogen (mg/L) | 322.2 | 308.6 | 213.0 | 501.4 | 45.3 | 308.7 | 308.6 | 169.9 | 437.8 | 7.2 | 0.000*** | |
| INR | 1.19 | 1.1 | 0.9 | 2.4 | 0.2 | 1.15 | 1.1 | 0.8 | 7.0 | 0.4 | 0.000*** | |
| PT (Sec) | 14.1 | 13.1 | 10.9 | 27.7 | 2.3 | 13.6 | 13.0 | 9.1 | 74.9 | 3.8 | 0.000*** | |
| Procalcitonin (μg/L) | 1.1 | 0.1 | 0.12 | 88.0 | 6.7 | 0.1 | 0.1 | 0.1 | 27.0 | 0.8 | 0.000*** | |
| ESR (mm/h) | 38.0 | 11.0 | 2.0 | 140.0 | 41.1 | 13.9 | 11.0 | 2.0 | 120.0 | 10.8 | 0.000*** | |
| Troponin (ng/L) | 46.2 | 10.0 | 8.9 | 1500.0 | 150.0 | 33.3 | 10.0 | 10.0 | 2500.0 | 541.9 | 0.000*** | |
| aPPT (Sec) | 32.6 | 29.8 | 19.9 | 94.6 | 8.5 | 30.3 | 29.8 | 12.0 | 101.0 | 4.1 | 0.002 | |
| PLT, ×109/L | 243.4 | 232.5 | 17.0 | 715.0 | 87.2 | 261.6 | 253.0 | 9.0 | 768.0 | 74.2 | 0.000*** | |
| LYM, ×109/L | 1.5 | 1.4 | 0.17 | 3.6 | 0.75 | 2.3 | 2.1 | 0.2 | 60.5 | 1.8 | 0.000*** | |
| NEU, ×109/L | 5.04 | 4.27 | 1.02 | 20.0 | 3.0 | 5.1 | 4.5 | 0.8 | 22.2 | 2.6 | 0.453 | |
| WBC, ×109/L | 7.2 | 6.7 | 2.3 | 24.0 | 3.14 | 8.2 | 7.6 | 1.5 | 68.3 | 3.3 | 0.000*** | |
| Biomarkers in the literature | LCR | 0.1 | 0.04 | 0.01 | 0.75 | 0.12 | 0.4 | 0.2 | 0.01 | 6.3 | 0.3 | 0.000*** |
| PLR | 212.3 | 161.7 | 30.9 | 1380.7 | 180.5 | 138.0 | 118.8 | 3.1 | 2527.3 | 93.2 | 0.000*** | |
| NLR | 5.0 | 2.8 | 0.6 | 55.7 | 6.76 | 2.8 | 2.1 | 0.1 | 50.9 | 2.9 | 0.000*** | |
| d-NLR | 2.9 | 1.9 | 0.5 | 18.6 | 2.7 | 1.9 | 1.5 | 0.1 | 25.5 | 1.5 | 0.000*** | |
| Biomarkers derived in this study | d-CL | 76.9 | 34.0 | 1.2 | 1147.1 | 127.1 | 5.19 | 1.25 | 0.1 | 357.1 | 16.5 | 0.000*** |
| d-CWL | 12.4 | 4.6 | 0.11 | 154.2 | 21.4 | 0.77 | 0.26 | 0.0 | 53.1 | 2.7 | 0.000*** | |
| d-CFL | 34497.5 | 3285.8 | 65.4 | 720000.0 | 95114.0 | 341.1 | 95.2 | 0.16 | 56713.3 | 1887.6 | 0.000*** | |
| d-CI | 93.5 | 61.2 | 3.3 | 484.3 | 96.8 | 10.5 | 5.2 | 2.1 | 331.1 | 24.7 | 0.000*** | |
| d-CT | 5302.6 | 609.0 | 30.2 | 340500.0 | 27969.3 | 326.3 | 40.7 | 10.0 | 335800.0 | 7118.9 | 0.000*** | |
| d-TI | 55.5 | 11.85 | 9.0 | 1800.0 | 177.6 | 41.1 | 10.9 | 7.5 | 37000.0 | 769.5 | 0.000*** | |
| d-PPT | 2486.0 | 19.9 | 12.9 | 340800.0 | 25223.9 | 62.1 | 15.6 | 10.9 | 52200.0 | 1091.9 | 0.000*** | |
| d-CIT | 6674.7 | 770.8 | 32.6 | 408600.0 | 34496.3 | 384.8 | 44.3 | 10.9 | 366022.0 | 8217.7 | 0.000*** | |
aPPT: activated partial prothrombin time; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; INR: international normalized ratio PT: prothrombin time; d-NLR: neutrophil count divided by the result of WBC count minus neutrophil count; LCR: lymphocyte to C-reactive protein ratio; NLR: neutrophil to lymphocyte ratio; PLR: platelet to lymphocyte ratio; INR: international normalized ratio; PLT: platelet count; LYM: lymphocyte count; WBC: white blood cell count; NEU: neutrophil count; d-CL: CRP to lymphocyte ratio; d-CWL: CRP divided by WBC times LYM; d-CFL: CRP times Ferritin result divided by LYM; d-CL: CRP to lymphocyte ratio; d-CWL: CRP divided by WBC times LYM; d-CFL: CRP times Ferritin result divided by LYM; d-CI: CRP times INR; d-CT: CRP times Troponin; d-TI: Troponin times INR; d-PPT: PT times Procalcitonin times Troponin; d-CIT: CRP times INR times Troponin (see method section). Bold p values were found to be significant. * p < 0.05, ** p < 0.01, *** p < 0.001 was considered significant. St D: Standart Devision.