Table 3.
Blood routine parameter and biomarker values of ICU group and non-ICU group on admission.
| Non-ICU |
ICU |
p-value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex Male (%) Female (%) |
1219 (49.6) 1239 (50.4) |
114 (60.0) 76 (40.0) |
0.006** | |||||||||
| Mean | Median | Min | Max | St D | Mean | Median | Min | Max | St D | |||
| Age | 53.6 | 55.0 | 18.0 | 102.0 | 18.6 | 72.9 | 75.0 | 20.0 | 100.0 | 72.9 | 0.000*** | |
| Blood routine parameters | CRP (mg/L) | 22.2 | 6.1 | 3.0 | 406.0 | 36.5 | 78.0 | 54.5 | 3.0 | 325.0 | 78.0 | 0.000*** |
| D-Dimer (μg/L) | 545.1 | 391.0 | 1.06 | 9240.0 | 684.44 | 1049.8 | 391.0 | 353.0 | 9610.0 | 1049.8 | 0.000*** | |
| Ferritin (μg/L) | 183.7 | 49.2 | 2.2 | 1650.0 | 281.8 | 345.9 | 49.2 | 49.2 | 1650. | 345.9 | 0.028* | |
| Fibrinogen (mg/L) | 320.5 | 308.6 | 90.2 | 668.1 | 55.3 | 322.2 | 308.6 | 213.0 | 501.4 | 322.2 | 0.150 | |
| INR | 1.11 | 1.1 | 0.8 | 17.8 | 0.4 | 1.19 | 1.1 | 0.9 | 2.4 | 1.2 | 0.000*** | |
| PT (Sec) | 13.3 | 13.0 | 10.1 | 181.0 | 4.0 | 14.1 | 13.1 | 10.9 | 27.7 | 14.1 | 0.000*** | |
| Procalcitonin (μg/L) | 0.2 | 0.1 | 0.1 | 24.0 | 0.6 | 1.1 | 0.1 | 0.12 | 88.0 | 1.1 | 0.000*** | |
| ESR (mm/h) | 17.8 | 11.0 | 2.0 | 124.0 | 18.0 | 38.0 | 11.0 | 2.0 | 140.0 | 38.0 | 0.000*** | |
| Troponin (ng/L) | 18.3 | 10.0 | 10.0 | 420.0 | 13.9 | 46.2 | 10.0 | 8.9 | 1500.0 | 46.2 | 0.000*** | |
| aPPT (Sec) | 31.2 | 29.8 | 12.0 | 101.0 | 5.5 | 32.6 | 29.8 | 19.9 | 94.6 | 32.6 | 0.547 | |
| PLT, ×109/L | 241.6 | 229.0 | 11.0 | 745.0 | 89.1 | 243.4 | 232.5 | 17.0 | 715.0 | 243.4 | 0.841 | |
| LYM, ×109/L | 1.7 | 1.4 | 0.1 | 90.3 | 3.0 | 1.5 | 1.4 | 0.17 | 3.6 | 1.5 | 0.554 | |
| NEU, ×109/L | 5.3 | 4.3 | 0.5 | 66.4 | 3.8 | 5.04 | 4.27 | 1.02 | 20.0 | 5.04 | 0.115 | |
| WBC, ×109/L | 7.7 | 6.7 | 0.4 | 127.0 | 5.2 | 7.2 | 6.7 | 2.3 | 24.0 | 7.2 | 0.088 | |
| Biomarkers in the literature | LCR | 0.3 | 0.2 | 0.01 | 22.5 | 0.7 | 0.1 | 0.04 | 0.01 | 0.75 | 0.1 | 0.000*** |
| PLR | 214.5 | 155.2 | 1.6 | 3054.6 | 185.0 | 212.3 | 161.7 | 30.9 | 1380.7 | 212.3 | 0.090 | |
| NLR | 5.8 | 2.7 | 0.1 | 255.7 | 10.9 | 5.0 | 2.8 | 0.6 | 55.7 | 5.0 | 0.055 | |
| d-NLR | 3.3 | 1.9 | 0.1 | 84.0 | 4.2 | 2.9 | 1.9 | 0.5 | 18.6 | 2.9 | 0.268 | |
| Biomarkers derived in this study | d-CL | 21.2 | 5.5 | 0.04 | 1923.1 | 59.3 | 76.9 | 34.0 | 1.2 | 1147.1 | 127.1 | 0.000*** |
| d-CWL | 3.57 | 0.83 | 0.0 | 209.8 | 10.6 | 12.4 | 4.6 | 0.11 | 154.2 | 21.4 | 0.000*** | |
| d-CFL | 6663.4 | 450.0 | 2.18 | 621117.5 | 27224.5 | 34497.5 | 3285.8 | 65.4 | 720000.0 | 95114.0 | 0.000*** | |
| d-CI | 23.3 | 7.3 | 3.9 | 407.1 | 36.5 | 93.5 | 61.2 | 3.3 | 484.3 | 96.8 | 0.000*** | |
| d-CT | 414.7 | 64.1 | 30.0 | 195670.0 | 4916.1 | 5302.6 | 609.0 | 30.2 | 340500.0 | 27969.3 | 0.000*** | |
| d-TI | 20.2 | 10.9 | 8.3 | 4578.0 | 146.9 | 55.5 | 11.85 | 9.0 | 1800.0 | 177.6 | 0.000*** | |
| d-PPT | 42.15 | 15.6 | 12.1 | 8977.8 | 320.9 | 2486.0 | 19.9 | 12.9 | 340800.0 | 25223.9 | 0.000*** | |
| d-CIT | 460.4 | 70.3 | 25.1 | 213280.3 | 5475.6 | 6674.7 | 770.8 | 32.6 | 408600.0 | 34496.3 | 0.000*** | |
aPPT: activated partial prothrombin time; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; INR: international normalized ratio PT: prothrombin time; d-NLR: neutrophil count divided by the result of WBC count minus neutrophil count; LCR: lymphocyte to C-reactive protein ratio; NLR: neutrophil to lymphocyte ratio; PLR: platelet to lymphocyte ratio; INR: international normalized ratio; PLT: platelet count; LYM: lymphocyte count; WBC: white blood cell count; NEU: neutrophil count; d-CL: CRP to lymphocyte ratio; d-CWL: CRP divided by WBC times LYM; d-CFL: CRP times Ferritin result divided by LYM; d-CI: CRP times INR; d-CT: CRP times Troponin; d-TI: Troponin times INR; d-PPT: PT times Procalcitonin times Troponin; d-CIT: CRP times INR times Troponin (see method section). Bold p values were found to be significant. * p < 0.05, ** p < 0.01, *** p < 0.001 was considered significant. St D: Standart Devision.