Table 1.
EV‐DNA clinical studies
| References | Clinical condition | Summary | |
|---|---|---|---|
| Cancer | |||
| Choi et al. [66], Montermini et al. [69] | Lung and epidermal cancer | EGFR inhibitors increased emission of EVs harboring EGFR and gDNA in vitro | |
| Yokoi et al. [43] | Ovarian cancer | Treatment with olaparib and topotecan increased DNA in ovarian cancer cell exosomes | |
| Yang et al. [71], Allenson et al. [72], Bernard et al. [73] | PDAC |
KRASG12D and TP53R273H mutations can distinguish healthy controls and patients with pancreas‐associated pathologies from PDAC patients. KRAS mutations can differentiate between stages of disease and are associated with disease‐free survival after resection. EV‐DNA level after neoadjuvant therapy can predict response; MAF is associated with disease progression and a predictor of progression‐free and overall survival |
|
| Garcia‐Romero et al. [75] | Glioma | DNA‐containing EVs can cross the BBB and can be isolated from peripheral blood | |
| Mata‐Rocha et al. [74] | Cervical cancer | EV‐DNA, HPV E6, and E7 oncogenes can be detected in pap smear samples | |
| Lee et al. [76] | Bladder carcinoma | Bladder cancer‐associated mutations amplified in urinary EV‐DNA | |
| Cancer treatment adverse effects | |||
| Lian et al. [78] | Irinotecan‐induced diarrhea | DNA‐containing EVs from irinotecan‐treated cells can launch inflammation pathways in immune cells through AIM2 | |
| Ariyoshi et al. [79] | Radiation‐induced bystander effect | EVs carrying mtDNA induced DNA damage in human dermal fibroblast cells | |
| Infections | |||
|
Sukriti et al. [82] Sanada et al. [81] |
Hepatitis B | EVs isolated from CHB carriers carry HBV DNA and transmit HBV DNA into noninfected cells | |
| Morris‐Love et al. [83] | Progressive multifocal leukoencephalopathy | JC polyomavirus can be released from and transmitted to glia by EVs | |
| De Carolis et al. [84] | HPV infection | EV HPV DNA is a trigger for breast cancer niche aggressiveness | |
| Cho et al. [85] | Tuberculosis | EV‐DNA can detect M. tuberculosis DNA in respiratory samples | |
| Pregnancy and prenatal diagnosis | |||
| Orozco et al. [88] | Preeclampsia | Term preeclamptic women had higher levels of EV‐DNA than control pregnant women | |