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. 2021 May 31;9(1):e002187. doi: 10.1136/bmjdrc-2021-002187

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Trends for HbA1c and risk factors associated with type 1 diabetes in patients between 18 and 75 years of age stratified by age at onset of disease and sex. Analyses were performed using mixed linear regression and generalized linear mixed models. Age, age at onset and the interaction between age and age at onset were set as fixed effects, with a random participant effect. Panels C and D show additional adjustment for antihypertensives. Panels E and F show additional adjustment for statin use. Panels A–F show analysis of each year between the ages of 18 and 75 years. Panels G–J show analysis of 4-year age intervals from 18 to 25 years of age to 71–75 years of age. eGFR, estimated glomerular filtration rate; LDL, low-denisty lipoprotein.