. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Eur Urol Oncol. 2021 Jan 7;4(3):464–472. doi: 10.1016/j.euo.2020.12.006

Table 2 –

Hazard ratios and p values for covariates identified with p < 0.2 in univariable Cox regression for patients with advanced urothelial cancer treated with first-line immune checkpoint inhibitors

Covariate	Hazard ratio (95% CI) on UVA	p value on UVA	Hazard ratio (95% CI) on MVA	p value on MVA
ECOG PS 2+ (vs 0–1)	1.96 (1.46–2.62)	<0.001	1.61 (1.17–2.21)	0.003
Albumin^a	0.53 (0.43–0.65)	<0.001	0.64 (0.47–0.86)	0.004
Hemoglobin^a	0.90 (0.84–0.96)	0.001	1.00 (0.93–1.09)	0.934
ANC^a	1.03 (1.02–1.05)	<0.001	0.98 (0.95–1.00)	0.055
NLR^a	1.04 (1.03–1.05)	<0.001	1.04 (1.02–1.06)	<0.001
Platelet count^a	1.00 (1.00–1.00)	0.006	1.00 (1.00–1.00)	0.401
Bone metastases	1.85 (1.37–2.52)	<0.001	1.37 (0.99–1.88)	0.055
Liver metastases	2.48 (1.78–3.44)	<0.001	2.23 (1.59–3.13)	<0.001

ANC = absolute neutrophil count; CI = confidence interval; ECOG = Eastern Cooperative Oncology Group; MVA = multivariate analysis; NLR = neutrophil to lymphocyte ratio; PS = performance status; UVA = univariate analysis.

Hazard ratio represents the ratio between groups one unit apart in continuous variable.