Skip to main content
. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Curr Opin Microbiol. 2021 Mar 1;61:16–24. doi: 10.1016/j.mib.2021.02.001

Figure 4: BamA catalyzes folding and insertion of beta-barrel proteins into the OM and is a highly promising antibiotic target.

Figure 4:

A) As part of the Bam complex, BamA folds ß-barrels for insertion into the outer membrane. A gate within BamA opens to engage the substrate, with the N-terminal side of the BamA ß-barrel forming hydrogen bonds with the C-terminus of the substrate. Darobactin is proposed to stabilize the closed conformation of BamA such that the substrate cannot be inserted into this gate. B) The structure of darobactin.