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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Expert Opin Ther Pat. 2021 Feb 8;31(6):549–561. doi: 10.1080/13543776.2021.1883587

Figure 2:

Figure 2:

TREM-2 pathway: TREM-2 interacts with one of its ligands by extracellular binding domain, and signal is propagated by DAP10 and DAP12, that activates PI3K and Syk, respectively. Splitting of TREM-2 from its stalk region by ADAMs results in the production of sTREM-2 which further inhibits TREM-2 signaling. Various possible approaches to target TREM-2 are also shown.