Table 1:

Meta-analysis results: list of top independent suggestive signals (P<5^*10⁻⁵).

Populations

Software

SNP

ChrX Position *

A1/A2

P_JP

P_CH

P_CAN

P_ITA

P_UK

P_meta

OR [95% CI]

Locus

ALL COHORTS

MR-MEGA

rs2239452

48775572

G/C

7.51e-06

5.41e-04

0.97

0.59

0.012

9.9e-08

1.17 [1.09–1.26]

PIM2

FEMALES-ALL COHORTS

MR-MEGA

rs2239452

48775572

G/C

4.35e-05

4.83e-4

0.48

0.36

5.11e-3

1.3e-05

1.11 [1.02–1.21]

PIM2

MALES-ALL COHORTS

MR-MEGA

rs201130692

132978723

-/A

0.015

0.88

5e-04

0.045

0.25

3.1e-05

3.16 [1.8–5.42]

GPC3

P_JP

P_CH

P_meta

OR [95% CI]

Locus

EAST ASIANS

META INTER

rs7059064

48837087

G/A

8.1e-06

1.75e-04

6.2e-09

1.33 [1.21–1.46]

GRIPAP1

EAST-ASIAN FEMALES

META INTER

rs2283734

8773556

A/G

4.15e-05

2.91e-04

4.64e-08

1.38 [1.23–1.56]

PIM2

EAST-ASIAN MALES

META INTER

rs113885580

38236645

G/A

0.0075

3.84e-04

1.06e-05

2.36 [1.61–3.46]

OTC

P_CAN

P_ITA

P_UK

P_meta

OR [95% CI]

Locus

CAUCASIANS

META INTER

rs62604490

116104694

G/A

0.36

0.0058

6.90e-05

2.98e-06

0.75 [0.66–0.85]

Intergenic

CAUCASIAN FEMALES

META INTER

rs62604490

116104694

G/A

0.47

7.59e-04

1.09e-04

4.24e-06

0.73 [0.63–0.83]

Intergenic

Only top signals of each suggestively/genome-wide associated region is reported (see also Figure 2).

For all SNPs presented in this table, directions among cohorts were always consistent, except for rs2239452 (all cohort analysis).

A1: tested allele (MAF allele). JP, Japanese; CH, Chinese; CAN, Canadians; ITA, Italians; UK, British; OR, odds ratio; CI, confidence interval.

^*According to human genome release Feb. 2009, GRCh37/hg19.