Table 1:

Cofactors and Ligands of Bacterial PAS Domains

Cofactor	Ligands/Signal	Example PAS Proteins
p-Coumaric acid	Blue light	Halorhodospira halophila PYP [30]
Flavin adenine dinucleotide (FAD)	Redox	Escherichia coli Aer [33,34] Azotobacter vinelandii NifL [35] Methylococcus capsulatus MmoS [36]
Flavin mononucleotide (FMN)	Blue light	Light-O2-Voltage (LOV) domains: Bacillus subtilis YtvA [37] Brucella abortus LOV-HK [38]
Riboflavin	Blue light	Erythrobacter litoralis EL346 [39]
Heme	O2, CO, NO	b-type heme: Bradyrhizobium japonicum FixL [40] E. coli DOS [41] Pseudomonas aeruginosa Aer2 [42] and BdlA [43] c-type heme: Geobacter sulfurreducens GSU0935 and GSU0582 [44]
FeS cluster	O2	Staphylococcus carnosus NreB [45]
-	Carbohydrates	Cellvibrio japonicus AbfS [46]
-	Fatty acids	Chloroflexus aurantiacus MltR [47] Mycobacterium tuberculosis Rv1364 Cronobacter turicensis RpfR [9]
-	Pyrazine	Vibrio cholerae VqmA [7]
-	Aromatic hydrocarbons	Pseudomonas putida TodS [48]
-	Metal2+	E. coli PhoQ [10] Staphylococcus aureus WalK [11]