Table 2.

HR for the hazard function for significant predictive variables for MOF in models with and without GRS

Variable	Without GRS HR per 1 unit (95% CI) in MOF	With GRS_fracture HR per 1 unit (95% CI) in MOF	With GRS_BMD HR per 1 unit (95% CI) in MOF	With GRS_eBMD HR per 1 unit (95% CI) in MOF
Age	1.07 (1.06 – 1.08)	1.07 (1.06 – 1.08)	1.07 (1.06 – 1.08)	1.07 (1.06 – 1.08)
Weight	0.99 (0.99 – 1.00)	0.99 (0.99 – 1.00)	0.99 (0.99 – 1.00)	0.99 (0.99 – 1.00)
Height	1.02 (1.01 – 1.03)	1.02 (1.01 – 1.03)	1.02 (1.01 – 1.03)	1.02 (1.01 – 1.03)
Previous osteoporotic fracture	1.54 (1.38 – 1.71)	1.54 (1.38 – 1.71)	1.54 (1.38 – 1.71)	1.53 (1.37 – 1.70)
Parental history of hip fracture	1.23 (1.07 – 1.41)	1.23 (1.07 – 1.41)	1.23 (1.07 – 1.41)	1.22 (1.07 – 1.41)
Rheumatoid arthritis	1.18 (0.95 – 1.47)	1.18 (0.95 – 1.46)	1.18 (0.95 – 1.47)	1.18 (0.95 – 1.47)
Current smoking	1.29 (1.06 – 1.56)	1.29 (1.07 – 1.57)	1.29 (1.06 – 1.57)	1.29 (1.06 – 1.56)
Daily drinking > 3	1.08 (0.70 – 1.66)	1.08 (0.70 – 1.66)	1.08 (0.70 – 1.66)	1.08 (0.70 – 1.66)
Secondary osteoporosis	1.07 (0.96 – 1.20)	1.07 (0.96 – 1.20)	1.07 (0.96 – 1.20)	1.07 (0.96 – 1.20)
GRS
0–25%	NA	Ref	Ref	Ref
25–75%	NA	1.067 (0.94 – 1.21)	1.15 (0.90 – 1.46)	1.34 (1.05 – 1.70)
75–100%	NA	1.175 (1.00 – 1.38)	1.12 (0.86 – 1.46)	1.52 (1.17 – 1.98)

^*Significant results are in boldface.