Table 3.

HR for the hazard function for significant predictive variables for Hip fracture (HF) in models with and without GRS

Variable	Without GRS HR per 1 unit (95% CI) in HF	With GRS_fracture HR per 1 unit (95% CI) in HF	With GRS_BMD HR per 1 unit (95% CI) in HF	With GRS_eBMD HR per 1 unit (95% CI) in HF
Age	1.13 (1.11 – 1.15)	1.13 (1.11 – 1.15)	1.13 (1.12 – 1.15)	1.13 (1.11 – 1.15)
Weight	0.99 (0.98 – 0.99)	0.99 (0.98 – 0.99)	0.99 (0.98 – 0.99)	0.99 (0.98 – 0.99)
Height	1.04 (1.03 – 1.06)	1.04 (1.03 – 1.06)	1.04 (1.03 – 1.06)	1.04 (1.03 – 1.06)
Previous osteoporotic fracture	1.44 (1.24 – 1.68)	1.44 (1.24 – 1.68)	1.44 (1.24 – 1.67)	1.43 (1.23 – 1.67)
Parental history of hip fracture	1.30 (1.07 – 1.57)	1.30 (1.07 – 1.57)	1.29 (1.06 – 1.56)	1.29 (1.07 – 1.57)
Rheumatoid arthritis	1.62 (1.23 – 2.14)	1.62 (1.22 – 2.14)	1.61 (1.22 – 2.13)	1.63 (1.23 – 2.15)
Current smoking	1.29 (1.06 – 1.56)	1.33 (0.99 – 1.79)	1.33 (0.99 – 1.79)	1.33 (0.99 – 1.79)
Daily drinking > 3	0.88 (0.46 – 1.70)	0.88 (0.45 – 1.70)	0.88 (0.45 – 1.69)	0.88 (0.46 – 1.71)
Secondary osteoporosis	1.14 (0.97 – 1.34)	1.14 (0.97 – 1.34)	1.14 (0.97 – 1.34)	1.14 (0.97 – 1.34)
GRS
0–25%	NA	Ref	Ref	Ref
25–75%	NA	1.03 (0.87 – 1.24)	1.14 (0.80 – 1.60)	1.16 (0.82 – 1.64)
75–100%	NA	1.01 (0.80 – 1.28)	0.97 (0.67 – 1.42)	1.43 (0.98 – 2.10)

^*Significant results are in boldface.