Table 5:
Reclassification table of 10-Year Major Osteoporotic Fracture (MOF) and Hip Fracture (HF) Stratified by Event Status. Results of Reclassification Analysis: Percent of reclassification compared with the FRAX base model (Model 1).
| Reclassification | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non-fracture group | Fracture group | NRI (category) |
p Value | NRI (continuous) |
p Value | IDI | p Value | |||
| Reclassification down | Reclassification up | Reclassification up | Reclassification down | |||||||
| GRS_fracture | ||||||||||
| MOF | 0.005 | 0.003 | 0.006 | 0.006 | 0.005 (−0.005 to 0.014) |
0.28 | 0.067 (0.014 to 0.121) |
0.01 | 0.005 (0.002 to 0.009) |
<.01 |
| HF | 0.000 | 0.001 | 0.007 | 0.000 | 0.007 (−0.003 to 0.016) |
0.18 | 0.020 (−0.083 to 0.124) |
0.70 | 0.000 (0.001 to 0.030) |
0.99 |
| GRS_BMD | ||||||||||
| MOF | 0.007 | 0.006 | 0.003 | 0.009 | −0.004 (−0.011 to 0.002) |
0.62 | 0.145 (0.084to 0.207) |
<.01 | 0.003 (0.001 to 0.006) |
0.01 |
| HF | 0.005 | 0.006 | 0.018 | 0.004 | 0.011 (−0.005 to 0.027) |
0.17 | −0.146 (−0.263 –0.029) |
0.02 | 0.001 (0.000 to 0.039) |
0.90 |
| GRS_eBMD | ||||||||||
| MOF | 0.020 | 0.016 | 0.025 | 0.022 | 0.007 (−0.006 to 0.020) |
0.33 | 0.114 (−0.001 to 0.123) |
<.01 | 0.021 (0.003 to 0.028) |
<.01 |
| HF | 0.027 | 0.026 | 0.025 | 0.029 | 0.014 (−0.030 to 0.025) |
0.85 | 0.222 (0.107 to 0.336) |
<.01 | 0.028 (0.003 to 0.041) |
<.01 |
*
Significant results are in boldface.
NRI=net reclassification improvement; IDI=integrated discriminative improvement; 95% confidence intervals are given within brackets.