Table 2.

Consequence of deletion of PRC and DNMT genes on normal intestinal development

Mouse Model	Complex	Modification	Phenotypic Anomaly	References
Ezh2 KO	PRC2	H3K27me1/2/3	No Significant difference in weight and intestinal morphology compare to WT	14, 17
Eed KO	PRC2	H3K27me1/2/3	Significant weight loss and severely degraded crypt	13, 18
Ring1a/b KO	PRC1	H2AK119UB	Significant weight loss and severely degraded crypt	149
Bmi1 KO	PRC1	H2AK119UB	Significantly shorter small intestine and reduced cycling crypt cell	150
Dnmt1 KO	Dnmt1	Methylated Cytosine	Smaller in size with shorter GI track, villus atrophy in neo-natal, and degeneration of GI smooth muscle	15, 150–152
Dnmt3b and Dnmt1 KO	Dnmt1 and Dnmt3	Methylated Cytosine	Significant reduction in weight. Increase apoptosis and degradation of villi and crypt	153