Table 1.

Types of Biomarkers

Type of biomarker	Definition
Risk stratification	Biomarker that predicts the future development of HCC in an at-risk patient
Early detection	Biomarker that detects HCC at an early tumor stage, when therapy can be delivered which would reduce HCC-related mortality
Diagnosis	Biomarker that can confirm or exclude presence of HCC in patients with a suspicious nodule or clinical concern for HCC
Prognosis	Biomarker that predicts overall cancer outcome, regardless of treatment
Treatment response	Biomarker that predicts favorable or unfavorable response to a specific treatment

HCC, hepatocellular carcinoma.