Figure 2.

A, The elements of innate immunity that are involved in Nlrp3 inflammasome activation and whose attenuation decreases HSPC migration after transplantation into recipient BM. Migration of transplanted HSPCs up a chemotactic gradient of BM chemoattractants is decreased by impaired Nlrp3 function as well as pannexin 1, P2X4, P2X7, and caspase 1 deficiency. B, The same effect is shown for Nlrp3 inflammasome activation components in the BM microenvironment of transplantation recipients. To home and engraft transplanted HSPCs, BM microenvironment cells require normal expression of the Nlrp3 inflammasome, pannexin 1, P2X4, P2X7, and caspase 1. Red asterisks indicate elements whose attenuation results in poor homing and engraftment in our recently published or preliminary results.