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. 2021 Jun 2;12(6):566. doi: 10.1038/s41419-021-03839-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Low-magnification scan of the pancreas at 7 days after transplantation of Luc⁺ VT680⁺ MSC; box indicates the area with a high VT680 signal; B Immunofluorescence images of the region indicated in (A). CD68 immunostaining denotes macrophages infiltrated at the transplantation site; CD45 immunostaining demarcates hematopoietic cells; C High-resolution microscopy of the region indicated in (A) showing the presence of cells with co-localized signal of VT680 and CD68 molecule (upper image) and co-localized signal of VT680 and CD45 molecule (lower image), thus suggesting the presence of macrophages that engulfed VT680⁺ MSC or VT680⁺ MSC-derived apoptotic bodies. D Flow cytometry analysis of peritoneal macrophages isolated from syngeneic mice co-cultured with healthy (control) or apoptotic MSC. Apoptotic MSC were obtained after 48-h culture with pro-inflammatory cytokines. Note the increased phagocytic activity of macrophages when in presence of apoptotic cells as compared to healthy cells.