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. 2021 Jun 1;11:11427. doi: 10.1038/s41598-021-91012-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Significance testing of ovarian signature scores stratified by clinical response. ssGSEA was applied with gene signature sets tailored to ovarian cancer, resulting in per-signature scores normalized to the range 0–1. The clear cell signature is significant in complete responders and the proliferative signature was significantly different in patients who exhibited progressive disease. The PR* group comprises one patient classified as PR by RECIST protocols and one exceptional patient (see “Methods”). Image was created using Prism version 8.3.0 (https://www.graphpad.com/).