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. 2021 Apr 30;35(6):1587–1599. doi: 10.1038/s41433-021-01393-5

Fig. 2. Plasma miRNA profiles of NPDR and NDR subjects.

Fig. 2

A A heatmap shows the miRNAs with >1.5 fold changes in expression. The miRNAs are hierarchically clustered on the y-axis based on their expression. B A volcano plot showing RNA sequencing results for the comparison of mild NPDR and NDR patients. The line indicates a false discovery rate (FDR)–adjusted P-value of 0.05. Individual microRNAs are displayed by their FDR-adjusted P-value. The up-regulated miRNAs are shown in red, while the down-regulated miRNAs are in green. C A heatmap shows the 28 differential miRNAs that are reported to be related to the development of DR. The expression index is colour-coded with green indicating down-regulation and red indicating up-regulation.