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. 2021 Jun 1;11:11478. doi: 10.1038/s41598-021-90748-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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4F2hc signalling pathway. Cell cycle analysis was performed with si4F2hc (si4F2hc-1 and si4F2hc-2) and compared with a control group (A to D). After 72 h or 96 h, si4F2hc (si4F2hc-1 and si4F2hc-2) downregulation of SKP2, phosphorylation of AKT and MAPK, and increased expression of p21 and p27 (E). Data represent three independent experiments with similar results.