Table 1.
Characteristics of patients with R0 vs R1 resection margin
| R0 48,367 |
R1 8165 |
P value | |
|---|---|---|---|
| Characteristics | |||
| Age at diagnosis, median (IQR) | 67 (59, 74) | 67 (59, 74) | < 0.001 |
| Age < 70 | 29,162 (60.3%) | 4750 (58.2%) | < 0.001 |
| Age ≥ 70 | 19,205 (39.7%) | 3415 (41.8%) | |
| Sex, N (%) | < 0.001 | ||
| Male | 24,261 (50.2%) | 4322 (52.9%) | |
| Female | 24,106 (49.8%) | 3843 (47.1%) | |
| Race, N (%) | 0.005 | ||
| White | 39,397 (81.5%) | 6710 (82.2%) | |
| African-American | 4688 (9.7%) | 703 (8.6%) | |
| Asian/PI | 1239 (2.6%) | 242 (3.0%) | |
| Other/unknown | 2228 (4.6%) | 387 (4.7%) | |
| Insurance type, N (%) | 0.001 | ||
| Private | 18,352 (37.9%) | 2973 (36.4%) | |
| Medicaid | 2234 (4.6%) | 367 (4.5%) | |
| Medicare | 25,431 (52.6%) | 4479 (54.9%) | |
| Not insured | 687 (1.4%) | 94 (1.2%) | |
| Other/unknown | 1663 (3.4%) | 252 (3.1%) | |
| Income ($USD), N (%) | 0.074 | ||
| < $38,000 | 7637 (15.8%) | 1199 (14.7%) | |
| $38,000–$47,999 | 10,786 (22.4%) | 1843 (22.7%) | |
| $48,000–$62,999 | 12,925 (26.8%) | 2183 (26.8%) | |
| > $63 k | 16,835 (34.9%) | 2906 (35.7%) | |
| Education, N (%) | 0.230 | ||
| 21%+ | 7134 (14.8%) | 1161 (14.3%) | |
| 13–20.9% | 12,164 (25.2%) | 2057 (25.3%) | |
| 7–12.9% | 16,017 (33.2%) | 2785 (34.2%) | |
| < 7% | 12,888 (26.7%) | 2129 (26.2%) | |
| Patient urban/rural location, N (%) | 0.252 | ||
| Metro areas | 39,358 (81.4%) | 6701 (82.1%) | |
| Urban Metro-Adjacent | 4890 (10.1%) | 775 (9.5%) | |
| Urban Not Metro-Adjacent | 1944 (4.0%) | 311 (3.8%) | |
| Rural | 2175 (4.5%) | 378 (4.6%) | |
| Charlson-Deyo Score, N (%) | < 0.001 | ||
| 0 | 31,827 (65.8%) | 5096 (62.4%) | |
| 1 | 12,472 (25.8%) | 2272 (27.8%) | |
| 2 | 2912 (6.0%) | 560 (6.9%) | |
| >3 | 1156 (2.4%) | 237 (2.9%) | |
| Differentiation | < 0.001 | ||
| Well differentiated, differentiated, NOS | 4891 (10.1%) | 671 (8.2%) | |
| Moderately differentiated, moderately well differentiated, intermediate differentiation | 22,266 (46.0%) | 3814 (46.7%) | |
| Poorly differentiated | 14,434 (29.8%) | 2915 (35.7%) | |
| Undifferentiated, anaplastic, unknown | 6776 (14.1%) | 765 (9.4%) | |
| Stage | |||
| Stage I | 8828 (18.3%) | 469 (5.7%) | < 0.001 |
| Stage II | 38,328 (79.2%) | 7173 (87.9%) | |
| Stage III | 1211 (2.5%) | 523 (6.4%) | |
| Neoadjuvant treatment | < 0.001 | ||
| No neoadjuvant | 35,672 (83.2%) | 6159 (87.1%) | |
| Neoadjuvant chemoradiation (CRT) | 3530 (8.2%) | 358 (5.1%) | |
| Neoadjuvant chemotherapy | 3564 (8.3%) | 539 (7.6%) | |
| Neoadjuvant radiation | 121 (0.3%) | 15 (0.2%) | |
| Adjuvant treatment | 17,658 (41.2%) | 2453 (34.7%) | |
| No adjuvant | 17,658 (41.2%) | 2453 (34.7%) | |
| Adjuvant chemoradiation | 9716 (22.7%) | 2531 (35.8%) | |
| Adjuvant chemotherapy | 14,960 (34.9%) | 1926 (27.2%) | |
| Adjuvant radiation | 553 (1.3%) | 161 (2.3%) | |
| Surgical approach | < 0.001 | ||
| Open or approach unspecified | 20,721 (77.8%) | 3463 (80.6%) | |
| Robotic assisted | 892 (3.3%) | 134 (3.1%) | |
| Robotic converted to open | 136 (0.5%) | 32 (0.7%) | |
| Laparoscopic | 3690 (13.8%) | 439 (10.2%) | |
| Laparoscopic converted to open | 1207 (4.5%) | 231 (5.4%) | |
| Type of surgery | < 0.01 | ||
| Partial pancreatectomy | 7661 (15.8%) | 1057 (12.9%) | |
| Local or partial pancreatectomy and duodenectomy | 3729 (7.7%) | 544 (6.7%) | |
| Without distal/partial gastrectomy | 4590 (9.5%) | 851 (10.4%) | |
| With partial gastrectomy (Whipple) | 22,464 (46.4%) | 4216 (51.6%) | |
| Total pancreatectomy | 1825 (3.8%) | 233 (2.9%) | |
| Total pancreatectomy and subtotal gastrectomy/duodenectomy | 4332 (9.0%) | 761 (9.3%) | |
| Extended pancreatoduodenectomy | 2730 (5.6%) | 425 (5.2%) | |
| Other | 1036 (2.1%) | 414 (1.0%) | |
| Hospital type, N (%) | 1682 (3.5%) | 320 (4.0%) | < 0.001 |
| Community Cancer Program | |||
| Comprehensive Community Cancer Program | 12,456 (26.2%) | 2284 (28.2%) | |
| Academic/Research Program | 27,373 (57.6%) | 4192 (51.8%) | |
| Integrated Network Cancer Program | 6050 (12.7%) | 1297 (16.0%) | |
| Surgical inpatient stay, days from surgery, median (IQR) | 8 (6, 12) | 9 (7, 14) | < 0.001 |
| Readmission within 30 days of surgical discharge | < 0.001 | ||
| Unplanned readmission within 30 days of discharge | 3354 (6.9%) | 672 (8.2%) | |
| 30-day mortality | < 0.001 | ||
| Patient died 30 or fewer days after surgery performed | 1149 (2.7%) | 324 (4.4%) | |
| 90-day mortality | < 0.001 | ||
| Patient died 90 or fewer days after surgery performed | 2314 (5.4%) | 671 (9.0%) |