Figure 5.
PIP3 coordination induces the P loop conformational change
(A) A snapshot highlighting P loop and protruded PIP3 from the bilayer surface at the active site.
(B) Deviations of the phosphate atoms of PIP2 and PIP3 from the averaged position of the phosphate atoms of DOPC and DOPS for the apo and holo bilayer leaflets in the absence and presence of the protein, respectively. The red and black lines in the box graphs indicate the mean and median values, respectively, and whiskers above and below the box indicate the 90th and 10th percentiles.
(C) The open conformation of P loop with the coordination of PIP3 at the active site.