Figure 7.
Multi-modal analysis reveals unanticipated protein-gene-cell relationships
(A and B) Plasma proteins from proteomics data analyzed as in Figure 3 were selected based upon increasing expression over time and across all 10 donors in both experiments. Normalized protein expression (y axis) over time since blood draw (x axis) is shown, with individual donors indicated by color.
(C and D) Single-cell RNA-seq data (analyzed as in Figure 4) from all 10 donors in both experiments were queried for transcripts encoding TNFSF14 and its receptors (C) or BACH1 and a selection of its transcriptional targets related to oxidative stress (D) and plotted by cell type. Charts show the normalized and scaled RNA count (y axis) for hours since blood draw (x axis). Individual donors are indicated by color.