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. 2021 Mar 10;151(6):1507–1516. doi: 10.1093/jn/nxab032

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Effect of indole on gene expression levels implicated in (A) intestinal barrier function, (B) inflammation, and (C) immune response in the ileum in ob/+ and ob/ob mice in experiment 1. Two-way ANOVA was used with genotype and indole treatment as fixed effects and the cage as random effect. Data are presented as means ± SEM, n ≥6/group. Ccl2, C-C motif chemokine ligand 2; Cldn2, Claudin 2; Foxp3, Forkhead box P3; Ido1, Indoleamine 2,3-dioxygenase 1; Ifng, Interferon γ; Muc2, Mucin 2; NS, not significant (P ≥ 0.05); ob/+ C, control ob/+ mice; ob/+ I, indole-treated ob/+ mice; ob/ob C, control ob/ob mice; ob/ob I, indole-treated ob/ob mice; Ocln, Occludin; Tjp1, Tight junction protein 1.