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. 2021 Jun 1;11:11456. doi: 10.1038/s41598-021-90872-6

Figure 3.

Figure 3

Testicular protein expression of IL6 signaling pathway components via JAK-STAT in IL6KO mice: expression of IL6R (a); pJAK1/JAK1 (b), pSTAT3/STAT3 (c) and SOCS3 (d) normalized by ACTB, and their respective representative western blot images. Lack of Il6 decreases IL6R (p = 0.0286) and enhances SOCS3 (p = 0.0286) expression with no changes on JAK1-STAT3 expression. Full-length blots are presented in Supplementary Fig. 2. *p < 0.05, Mann–Whitney test. Values expressed as mean ± SEM. Results are representative of samples from 4 to 6 mice per group. ACTB – beta-actin; IL6R—interleukin-6 receptor, alpha; JAK1—Janus kinase 1; pJAK1—phosphorylated JAK1; STAT3—signal transducer and activator transcription 3; pSTAT3—phosphorylated STAT3; SOCS3—suppressor of cytokine signaling 3.