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. 2021 Jun 1;6:30. doi: 10.1038/s41536-021-00140-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — hPSC-CMs obtained from the differentiation of pluripotent stem cells present fetal-like features in respect to structural and ultrastructural organization, contractile force, metabolism, and electrophysiological function. AP action potential, ECC excitation–contraction coupling, FFR force–frequency relationship, hPSCs human pluripotent stem cells, NCX sodium–calcium exchanger, PRP post-rest potentiation, RMP resting membrane potential, RYR2 ryanodine receptor type 2, SERCA2a sarcoplasmic/endoplasmic reticulum calcium-ATPase 2a, SR/ER sarcoplasmic/endoplasmic reticulum.