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. 2021 Jun 1;6:30. doi: 10.1038/s41536-021-00140-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — hPSC-CMs can develop adult-like features with training based on functional stimuli, cues to guide their structural organization, relevant biochemical factors, and by manipulating the genetic program. CMT cardiac microtissue, EHT engineered heart tissue, EV extracellular vesicle, MSC mesenchymal stem cell, SMC smooth muscle cell, T3 triiodothyronine.