Table 1.
Human clinical studies for the generation of disease and/or patient-specific models of cardiac diseases (Trial Identifier: www.clinicaltrials.gov).
| Study title | Condition(s) | Study type | Trial identifier |
|---|---|---|---|
| Individualized early risk assessment for heart diseases (IndivuHeart) | Hypertrophic cardiomyopathy; dilated cardiomyopathy | Observational | NCT02417311 |
| Investigating hereditary cardiac disease by reprogramming skin cells to heart muscle (CLUE) | Electrophysiology of iPSC-CM | Observational | NCT01865981 |
| Modeling and pharmacological targeting of genetic cardiomyopathy in children via iPSC-CM (DMDstem) | Familial cardiomyopathy | Interventional | NCT03696628 |
| Molecular mechanism identification in inherited arrhythmias and valvulopathies from iPSC (Diag-iPS) | Inherited arrhythmias and valvulopathies | Interventional | NCT01734356 |
| Evaluating cardiovascular phenotypes using iPSC | Coronary artery disease | Observational | NCT01517425 |
| Generation of Marfan syndrome and Fontan cardiovascular models using patient-specific iPSC | Marfan’s syndrome | Observational | NCT02815072 |
| Translational approaches to septic cardiomyopathy (TASC01) | Cardiomyopathies, sepsis, septic shock | Observational | NCT03252613 |
| CIQTP prolongation: role and mechanism in sudden cardiac death (IQARE-SCD) | Sudden cardiac death | Observational | NCT03387072 |
| Derivation of iPSC to heritable cardiac arrhythmias | Inherited cardiac arrhythmias; long QT syndrome; Brugada syndrome; catecholaminergic polymorphic ventricular tachycardia; early repolarization syndrome; arrhythmogenic cardiomyopathy; hypertrophic cardiomyopathy; dilated cardiomyopathy; muscular dystrophies (Duchenne, Becker, myotonic dystrophy) | Observational | NCT02413450 |
| Early MRI detection of myocardial deterioration as a preventive, disease staging, and prognostic biomarker in insulin resistance | Cardiomyopathies; insulin resistance; non-ischemic cardiomyopathy; cardiac fibrosis; diabetes | Observational | NCT03509441 |
| Characterization of patients with uncommon presentations and/or uncommon diseases associated with the cardiovascular system | Cardiomyopathy; Li-Fraumeni syndrome; Parkinson’s disease; atherosclerosis; cardiovascular capacity | Observational | NCT01143454 |
| UTHealth Turner syndrome research registry | Turner syndrome | Observational | NCT03185702 |
iPSC induced pluripotent stem cells, iPSC-CM induced pluripotent stem cells derived cardiomyocytes, MRI magnetic resonance imaging.