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. 2021 Jan 29;31(6):613–630. doi: 10.1038/s41422-020-00466-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic illustrations of L1 (panel (i)) and B1 (panel (ii)) RNA targeted by AMO/ASO or DNA FISH probes. b Representative images of L1 (green) and B1 (red) repeats revealed by DNA FISH in mESCs. DNA is labeled by DAPI (blue). All scale bars, 5 μm. c Representative images of DNA immuno-FISH analysis of L1 (green) and B1 (red) DNA repeats, and NCL protein (purple) in mESCs (n = 37), NSC (n = 23), NIH3T3 (n = 18), C2C12 (n = 11) and HeLa cells (n = 15). d Representative images of Oligopaint DNA FISH of individual sites in A or B compartments. Panel (i), three A-compartmental regions (F, H, R) with B1 DNA FISH; panel (ii), two B-compartmental regions (g, q) with L1 DNA FISH. See also Supplementary information, Fig. S5.