Table 2.
Genotype and allele distributions in control subjects and CAD patients.
| Variants | Model | Control, n (%) (n = 1082) | CAD, n (%) (n = 950) | CAD p-value (H-W) | Control p-value (H-W) | P-value∮ | |
|---|---|---|---|---|---|---|---|
| rs11583680(SNP1) | Genotypes | CC | 882 (81.52) | 750 (78.95) | |||
| CT | 187 (17.28) | 184 (19.37) | |||||
| TT | 13 (1.20) | 16 (1.68) | 0.294 | ||||
| Dominant model | CC | 882 (81.52) | 750 (78.95) | ||||
| TT + CT | 200 (18.48) | 200 (21.05) | 0.231 | 0.389 | 0.146 | ||
| Recessive model | TT | 13 (1.20) | 16 (1.68) | ||||
| CC + CT | 1069 (98.80) | 934 (98.32) | 0.360 | ||||
| Alleles | C allele | 1951 (90.16) | 1684 (88.63) | ||||
| T allele | 213 (9.84) | 216 (11.37) | 0.114 | ||||
|
rs2483205 (SNP2) |
Genotypes | CC | 523 (48.34) | 488 (51.37) | |||
| CT | 456 (42.14) | 402 (42.32) | |||||
| TT | 103 (9.25) | 60 (6.32) | 0.025∮ | ||||
| Dominant model | CC | 523 (48.34) | 488 (51.37) | ||||
| TT + CT | 559 (51.66) | 462 (48.63) | 0.057 | 0.803 | 0.173 | ||
| Recessive model | TT | 103 (9.52) | 60 (6.32) | ||||
| CC + CT | 979 (90.48) | 890 (93.68) | 0.008∮ | ||||
| Allele | C allele | 1502 (69.41) | 1298 (71.32) | ||||
| T allele | 662 (30.69) | 522 (28.78) | 0.189 | ||||
|
rs2495477 (SNP3) |
Genotypes | AA | 502 (46.40) | 463 (48.74) | |||
| AG | 486 (44.92) | 419 (44.11) | |||||
| GG | 94 (8.69) | 68 (7.16) | 0.342 | ||||
| Dominant model | AA | 502 (46.40) | 463 (48.74) | ||||
| GG + AG | 580 (53.60) | 487 (51.26) | 0.041* | 0.120 | 0.292 | ||
| Recessive model | GG | 94 (8.69) | 68 (7.16) | ||||
| AA + AG | 988 (91.31) | 882 (92.84) | 0.204 | ||||
| Allele | A allele | 1490 (68.9) | 1345 (70.79) | ||||
| G allele | 674 (31.1) | 555 (29.21) | 0.180 | ||||
|
rs562556 (SNP4) |
Genotypes | AA | 962 (88.91) | 879 (92.53) | |||
| AG | 118 (10.91) | 70 (7.37) | |||||
| GG | 2 (0.18) | 1 (0.11) | 0.020∮ | ||||
| Dominant model | AA | 962 (88.91) | 879 (92.53) | ||||
| GG + AG | 120 (11.09) | 71 (7.47) | 0.746 | 0.411 | 0.005∮ | ||
| Recessive model | GG | 2 (0.18) | 1 (0.11) | ||||
| AA + AG | 1080 (99.82) | 949 (99.89) | 0.641 | ||||
| Allele | A allele | 2042 (94.36) | 1828 (96.21) | ||||
| G allele | 122 (5.54) | 72 (3.79) | 0.006∮ | ||||
CAD coronary artery disease.
*p values < 0.05 for Hardy–Weinberg equilibrium in CAD patients and controls.
∮p values < 0.05 for distribution frequency for genotypes and alleles of the 4 SNPs in the PCSK9 gene.