Table 1.
Chronologic presentation of studies on naturally occurring OA applying autologous MSC.
| Author | # Patients | Groups/treatment | OA location | MSC source | Injection site | Dosage MSC (cells) | # Injections | Outcome | Side effects MSCs |
|---|---|---|---|---|---|---|---|---|---|
| Black et al., (28) | 21 | MSC: not specifiedControl: not specified | hip | fat | IA | 4.2–5 × 106 | 1 | + | No |
| Black et al., (35) | 14 | MSC: 14 | elbow | fat | IA | 3–5 × 106 | 1 | + | No |
| Guercio et al., (37) | 4 | MSC + HA: 2MSC + PRP: 2 | elbow | fat | IA | 3–5 × 106 | 1 | + | No |
| Yoon et al., (50) | 1 | MSC + surgery + HA: 1 | stifle | fat | IA | 1 × 106 | 1 | + | No |
| Vilar et al., (48) | 13 | MSC + PRP: 8Control: 5 | hip | fat | IA | 15 × 106 | 1 | + | No |
| Cuervo et al., (36) | 35 | MSC: 18PRP: 17 | hip | fat | IA | 30 × 106 | 1 | + | No |
| Nicpon et al., (42) | 12 | MSC: 8Control: 4 | elbow | fat | IA | 1.5 × 106 | 1 | + | No |
| Vilar et al., (46) | 15 | MSC: 10Control: 5 | hip | fat | IA | 15 × 106 | 1 | + | Yes (1 dog) |
| Mohoric et al., (41) | 10 (20 stifles) | MSC: 10 stiflesControl: 10 stifles | stifle | fat | IA | 2–3 × 106 | 1 | + | No |
| Vilar et al., (47) | 15 | MSC: 10Control: 5 | hip | fat | IA | 15 × 106 | 1 | + | No |
| Srzentic Drazilov et al., (45) | 10 | MSC: 10 | Different joints | fat | IA | >15 × 106 | 1 | + | No |