Table 4.
Chronologic presentation of model based studies applying autologous MSC.
| Author | # Patients | Groups/treatment | Type defect | Location cartilage defect | MSC source | Injection site | Dosage MSC (cells) | # Admini-strations | Outcome | Side effects MSCs |
|---|---|---|---|---|---|---|---|---|---|---|
| Mokbel et al., (55) | 32 | MSC 1 day after defect: 12MSC 1 month after defect: 12Control: 8 | Partial thickness cartilage | Lat. condyle femur | Bone marrow | IA | 7–8 × 106 | 1 | + | No |
| Qiang et al., (56) | 12 | MSC + scaffold: 8Control: 4 | Osteo-chondral | Bilateral condyle femur | Bone marrow | Implantation with scaffold | 1 × 106 | 1 | + | No |
| Miki et al., (59) | 24 (48 stifles) | 0 MSCs + 0% HA: 3 stifles 5 × 105 MSCs + 0.01% HA: 3 stifles 5 × 106 MSCs + 0.1% HA: 3 stifles 5 × 107 MSCs + 0.5% HA: 3 stifles 0 MSCs + 0.5% HA: 3 stifles 5 × 105 MSCs+ 0% HA: 3 stifles 5 × 106 MSCs+ 0.01% HA: 3 stifles 5 × 107 MSCs + 0.1% HA: 3 stifles 0 MSCs + 0.1% HA: 3 stifles 5 × 105 MSCs + 0.5% HA: 3 stifles 5 × 106 MSCs+ 0% HA: 3 stifles 5 × 107 MSCs+ 0.01% HA: 3 stifles 0 MSCs+ 0.01% HA: 3 stifles 5 × 105 MSCs + 0.1% HA: 3 stifles 5 × 106 MSCs + 0.5% HA: 3 stifles 5 × 107 MSCs+ 0% HA: 3 stifles |
Partial thickness cartilage | Med. condyle femur | synovium | IA | See column group/treatments | 1 | + | No |
| Yamasaki et al., (58) | 15 (30 stifles) | MSC + serum + HA: 15 stifles Serum + HA: 15 stifles |
Full thickness cartilage | Patellar groove | Bone marrow | Direct implantation in defect | 0.2–2.8 × 107 | 1 | + | No |
| Kazemi et al., 2017 (53) | 12 (24 stifles) | MSC + PRF: 12 stifles Control: 12 stifles |
Osteo-chondral | Med. condyle femur | Bone marrow | Direct implantation in defect | 1 × 106 | 1 | + | No |