Table 5.
Chronologic presentation of model based studies applying allogeneic MSC.
| Author | # Patients | Groups/treatment | Type defect | Location cartilage defect | MSC source | Injection site | Dosage MSC (cells) | # Admini-strations | Outcome | Side effects MSCs |
|---|---|---|---|---|---|---|---|---|---|---|
| Duan et al., (52) | 12 (24 stifles) | MSC + scaffold: 8 stifles Scaffold: 8 stifles Control: 8 stifles |
Osteo-chondral | Patellar groove | Bone marrow | Implantation with scaffold | 1 × 104 | 1 | + | No |
| Qiang et al., (57) | 12 (24 hips) | MSC + scaffold: 12 hipsControl: 12 hips | Osteo-chondral | Femoral head | Bone marrow | Implantation with scaffold | Seeded with 5 × 107/mL | 1 | - | No |
| Yun et al., (51) | 24 | MSC: 6PRP: 6MSC + PRP: 6Control: 6 | Cranial cruciate ligament | / | fat | IA | 1 × 107 | 4 | + | No |
| Li et al., (54) | 24 (48 stifles) | MSC + HA: 8HA: 8Control: 8 | Partial thickness cartilage | Bilateral condyle femur + patellar groove | Bone marrow | IA | 1 × 107 | 1 | + | No |
| Zhang et al., (63) | 8 | MSC: 4Control: 4 | cartilage | Condyle femur + patella | Umbilical cord | IA | 1 × 106 | 2 | + | No |