Figure 2.

Gastrointestinal dysmotility in HSV-1 infected mice. (A) The mice were OG dosed with non-absorbable FITC-labeled dextran and sacrificed 60 minutes later. Gastric emptying was calculated as the percentage of dextran retained in the stomach with respect to the total amount of fluorescence in the gastrointestinal tract. * denotes p < 0.01 vs sham infected mice. (B) Intestinal transit refers to the geometric center that is the center of the distribution of fluorescent dextran in the ileum. (C) The time (seconds, sec) required for the expulsion of a glass bead inserted into the rectum. * denotes p < 0.05 vs sham-infected mice (D) The number of fecal pellets expelled in 1 hour (hr). * denotes p < 0.05 vs the sham-infected mice. Data are reported as mean ± SEM. All the experiments were repeated 3 times; n=6-12 mice per group.