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. 2021 May 19;9:656849. doi: 10.3389/fcell.2021.656849

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Copyright © 2021 Sokpor, Xie, Nguyen and Tuoc.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The N⁶-methyladenosine (m⁶A) machinery and modification of messenger RNA (mRNA). (A) An illustration showing the m⁶A machinery. It is made of factors that can functionally be categorized as writers, erasers, and readers of m⁶A. The m⁶A marks are deposited by the methylation complex (writers), including METTL3, METTL14, and WTAP, which is counteracted by the m⁶A demethylases (FTO and ALKBH5), leading to m⁶A removal. The recognition of m⁶A marks is done by the readers or binding proteins as indicated. (B) Diagram showing a typical m⁶A distribution in regions of an mRNA located in the nucleus. (C) The m⁶A readout affects mRNA fates, including trafficking, stability, decay, translation, and localization.