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. 2021 May 19;9:669285. doi: 10.3389/fcell.2021.669285

FIGURE 4.

FIGURE 4

DCBLD2 regulates the sensitivity of CRC cells to 5-FU by affecting migration and invasion. (A) Scratch assay performed in HCT116 and CACO-2 cells transfected with control siRNA or DCBLD2 siRNA1/2 and treated with 5-FU or DMSO, respectively. Scale bars: 0.02 mm. (B) Transwell migration assay performed in HCT116 and CACO-2 cells transfected with control siRNA or DCBLD2 siRNA1/2 and treated with 5-FU or DMSO, respectively. Scale bars: 0.02 mm. (C) Transwell Matrigel invasion assay performed in HCT116 and CACO-2 cells transfected with control siRNA or DCBLD2 siRNA1/2 and treated with 5-FU or DMSO, respectively. Scale bars: 0.02 mm. All data are presented as the mean ± SD of three experiments (*p < 0.05, **p < 0.01, ***p < 0.001; n = 3, Mann–Whitney test).