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. 2021 May 19;11:626187. doi: 10.3389/fonc.2021.626187

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Copyright © 2021 Bispo, Farias, de Araujo-Souza, Cintra, Santos, Jorge, Castro, Wajnberg, Scherer, Genta, Carvalho, Villa, Sichero and Passetti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential gene expression profiles among cervical squamous cell carcinomas (SCC), cervical adenocarcinomas (ADC), and non-tumoral cervical tissue and HPV-negative (non-CC) samples. (A) Number of genes differentially expressed in each group. Transcription regulatory networks (TRN) of genes upregulated in SCC (B) and ADC (D), including transcription factors (purple squared), other protein-coding genes (green circle), long non-coding RNAs (lncRNA) (light blue circle), and pseudogenes (light orange circle). Ten most enriched Gene Ontology Biological processes involved in cervical SCC (C) and ADC (E) TRNs. Biological processes were grouped by enriched Gene Ontology (GO) Biological processes (y-axis) and sorted by lower logarithm scale of p-values (x-axis, p < 0.05), calculated by Enrichr (11).