Table 1.

Two-sample Mendelian randomisation demonstrates that strenuous sport and other exercise (SSOE) is a risk factor for ALS using a liberal instrument.

Instrument	Mendelian randomisation method	Beta	Standard error	p value
Liberal (p<1E-06)	Inverse variance weighted (fixed effects)	0.21	0.08	0.007
	Inverse variance weighted (multiplicative random effects)	0.21	0.08	0.01
	MR Egger	0.75	0.41	0.07
	Weighted median	0.22	0.11	0.05
	Weighted mode	0.52	0.25	0.04
	MR RAPS with overdispersion model	0.21	0.09	0.009
	MR RAPS without overdispersion model	0.24	0.08	0.005
Conservative (p<5E-08)	Inverse variance weighted (fixed effects)	0.28	0.16	0.07
	Inverse variance weighted (multiplicative random effects)	0.28	0.18	0.11
	MR Egger	-1.09	0.89	0.26
	Weighted median	0.17	0.22	0.44