Fig. 1.

Example of a signaling circuit composed by a receptor protein, A, 5 proteins that transduce the signal B, C, D, E and F, one of them being an inhibitor, and an effector protein, G, that ultimately triggers a function. The table represents the normalized gene expression values. The application of the formula below with the values in the table, starting with a hypothetical signal of 1 renders a final intensity signal of 0.452 in the example.