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. 2021 May 19;12:672737. doi: 10.3389/fimmu.2021.672737

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Copyright © 2021 Illing, van Hateren, Darley, Croft, Mifsud, King, Kostenko, Bharadwaj, McCluskey, Elliott and Purcell

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tapasin and abacavir differentially enhance the binding of fluorescent peptides. The extent that (A) tapasin, (B) abacavir, or (C) the combination of both enhanced the binding of fluorescent peptides to HLA-B*57:01fos molecules was compared over independent experiments. For each polarisation measurement taken in an experiment the enhancement factor was calculated by: dividing polarisation in the presence of tapasin (or abacavir or both) by the intrinsic polarisation level; multiplying by 100 to obtain a percentage; and calculating the mean enhancement for the experiment. The enhancement factors obtained from different experiments are shown as dots, with the mean average shown as a horizontal black bar, and the standard deviation of multiple experiments shown as a coloured vertical line edged with horizontal bars. Peptides are coloured according to their classification by mass spectrometry: abacavir facilitated = yellow, abacavir dependent = green, minimally affected = orange, abacavir inhibited = red.