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. 2021 Apr 25;31:102687. doi: 10.1016/j.nicl.2021.102687

Table 1.

Demographic and clinical features of participants.

C9orf72+ C9orf72- p
number 15 20 -
age (years) [range] 45.3 ± 10.6 (Fischl et al., 2002, Herholz et al., 1990, Herholz et al., 2002, Sanabria-Diaz et al., 2013, Ihaka and Gentleman, 1996, Benjamini and Hochberg, 1995, Rutherford et al., 2012, De Vocht et al., 2020, Mutsaerts et al., 2019, Bertrand et al., 2018, Lee et al., 2017, Walhout et al., 2015, Boeve et al., 2012, Cistaro et al., 2014, Josephs et al., 2014, Kerklaan et al., 2014, McDade et al., 2012, Van Laere et al., 2014) 56.0 ± 11.0[34–65] 0.0066
sex(male:female) 8:7 12:8 0.6933
handedness (right:left) 12:3 20:0 0.0365
education (years) 14 ± 3 13 ± 3 0.5051a
MMSE score [range] 29 ± 1 (Desikan et al., 2006, Fischl et al., 2002, Herholz et al., 1990, Herholz et al., 2002) 29± 1 (Dale et al., 1999, Desikan et al., 2006, Fischl et al., 2002, Herholz et al., 1990, Herholz et al., 2002) 0.2883a
FAB score [range] 17 ± 2 (Jacova et al., 2013, Papma et al., 2017, Popuri et al., 2018, Rohrer et al., 2015, Morbelli et al., 2016, Caroppo et al., 2015, Deters et al., 2014, Ou et al., 2019) 16 ± 2 (Popuri et al., 2018, Rohrer et al., 2015, Morbelli et al., 2016, Caroppo et al., 2015, Deters et al., 2014, Ou et al., 2019) 0.1655a
FBI score [range] 1 ± 1[0–4] 0 ± 1[0–4] 0.7943a
Manual Muscle Testing 100 ± 0.2[98–100] 100 ± 0.1[99–100] 0.8241a
ALS-FRS-R 19.4 ± 0.6 (Zimmer et al., 2017, Sweeney et al., 2018) 19. 6 ± 0.4 (Zimmer et al., 2017, Sweeney et al., 2018) 0.7792a
mean age FTD onset in family (years) 56 ± 9 56 ± 6 0.8806
years to mean age of FTD onset 11 ± 11 0 ± 10 0.0066

C9orf72+, C9orf72 mutation carrier; C9orf72-, non-carrier member of family with C9orf72 mutation; FAB, Frontal Assessment Battery (maximum score = 18); FBI, Frontal Behavioral Inventory (maximum score = 72); MMSE, Mini Mental State Exam (maximum score = 30); ALS-FRS-R, Amyotrophic Lateral Sclerosis – Functional Rating Scale - revised

a

Data did not follow normal distribution; therefore, non-parametric test (Wilcoxon rank sum) was employed.