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. 2021 May 19;12:670405. doi: 10.3389/fgene.2021.670405

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Copyright © 2021 Zhang, He, Gu, Liu, Li, Yang, Hao and Hua.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and validation of hub targets of nine miRNAs in EC. (A) Protein–protein interaction network analysis to identify hub targets of nine miRNAs. (B) Ten mRNAs were identified as hub targets, including BTRC, SIAH1, RNF138, CDC27, NEDD4L, MKRN1, RLIM, FBXO11, RNF34, MYLIP, FBXW7, RNF4, UBE3C, and RNF111. (C–P) RNF34 (C), MYLIP (D), FBXW7 (E), RNF4 (F), UBE3C (G), RNF111 (H), SIAH1 (I), RNF138 (J), CDC27 (K), MKRN1 (L), RLIM (M), FBXO11 (N), BTRC (O), and NEDD4L (P) were remarkably suppressed in EC tissues compared with normal samples.