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. 2021 May 26;22(1):560. doi: 10.3892/ol.2021.12821

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Dynamics of miRNAs in H9c2 cells during Dox treatment. Cluster analysis of miRNAs with altered miRNA expression, determined using high-throughput sequencing, were analyzed at 0, 12 and 24 h after Dox treatment. (A) A total of 76 differentially expressed miRNAs (RPM >10) were identified, whose expression levels changed ≥1.5-fold compared with the 0-h time point. The miRNA RPM values were normalized with log10-transformation before using cluster analysis. The 76 miRNAs were classified into 4 clusters (clusters 1–4) using the Hierarchical Clustering Explorer v3.5 software. (B) Dynamic miRNA expression curves for each cluster. miR/miRNA, microRNA; RPM, reads per million; Dox, doxorubicin.