Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 24;22(1):553. doi: 10.3892/ol.2021.12814

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Cameselle-García et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 5. — ATC with poorly differentiated areas (case 15). (A) Transition between poorly differentiated areas (asterisks) and ATC areas (arrows) (magnification, ×200). Morphological differences between (B) poorly differentiated and (C) ATC areas at a higher magnification (magnification, ×400). (D) PD-L1 expression was only detected in the ATC areas (arrows), but not in the poorly differentiated component (asterisks) (magnification, ×200). (E) ATC cells showed strong and diffuse positivity for PD-L1 (magnification, ×400). MLH1 expression at magnification (F) ×200 and (G) ×400 was found in the poorly differentiated areas (asterisk), but not in the ATC areas (arrows). CD163⁺ macrophages were not detected in (H) the poorly differentiated areas, but were heavily detected in (I) the ATC areas (magnification, ×400). ATC, anaplastic thyroid carcinoma; H&E, hematoxylin and eosin; PD-L1, programmed death ligand 1; MLH1, mutL homolog 1.