Table 2.

Factors related to the occurrence of AAD.

	SCF group (n = 221)	TZP group (n = 135)	P
Dosage (mg/kg/day)	54.0 (36.0–105.8)	94.5 (63.0–182.2)	/
Therapy course (day)	8 (6–11)	14 (8–21)	0.001*
Number of DDDs used	1.4 (1.0–1.5)	1.0 (0.9–1.0)	<0.001*
Empiric therapy	167 (76.32%)	105 (77.78%)	0.890
Targeted therapy	52 (23.68%)	30 (22.22%)
Combined antibiotics	111 (50.23%)	80 (59.26%)	0.461
Nutrition support	167 (76.32%)	125 (92.59%)	0.165

*P < 0.05.

SCF, cefoperazone/sulbactam; TZP, piperacillin/tazobactam; AAD, antibiotic-related diarrhea; DDD, defined daily dose.